![]() ![]() These variabilities can also be addressed through the use of electronic patient records linked with research databases. This includes fasting status, caffeine intake, smoking status, alcohol use and exercise, as well as specific time of sample collection. When it comes to patient-derived variations, the authors recommend careful documentation for long-term storage and future research purposes. Since approximately 85% of CSF proteins derive from blood, contamination with blood can also affect biobanked samples. Additionally, the specific cellular and biochemical composition of CSF as compared with blood (e.g., lower protein concentration and protease activity) can impact protein stability. This preanalytical variation includes factors related to the patient/donor as well as differences in collection techniques and assay performance. 1Īccording to the authors, pre-analytical errors make up 60% of total laboratory errors and represent a significant issue for CSF biomarker analysis. In a recent review, Willemse and Teunissen (2015) indicate that enhanced industry understanding of the value of CSF biobanking and strategies to address long-term storage quality control challenges could reap scientific rewards. This means that scientific collaboration for access to this resource is at a premium, requiring standardized sampling and storage protocols. Since the techniques for obtaining even lumbar CSF samples are invasive, samples from healthy controls are rare, and few large CSF biobanks exist. The identification of novel CSF biomarkers could allow for early diagnosis, prognostic prediction, disease monitoring and the development of neuroprotective treatments. For this reason, CSF is particularly valuable for analysis, including biomarker discovery. These include bacterial meningitis, multiple sclerosis and Alzheimer’s disease. ![]() Because cerebrospinal fluid (CSF) is adjacent to and interacts with the brain’s parenchyma, it yields brain-specific molecules reflective of the pathophysiology of neurological diseases and brain-based disorders. ![]()
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